Our research

 

          Our laboratory focuses on the molecular and cellular mechanisms by which kidneys regulate ionic transport and adapt to the environment in order to match renal excretion to the daily intake. 

Presently, our main projects concern

  • The maturation and trafficking of the Na/K/2Cl transporter in the thick ascending limb and its regulation and dysregulation in Bartter’s syndrome
  • The functional and structural characterization of Dent’s mutants of the CCL5 Na/Cl exchanger
  • The regulation of ion transport in the distal nephron by proteinase activated receptor 2
  • Sodium retention and edema formation in nephrotic syndrome
  • Potassium metabolism and its alteration during gestation and circadian cycle
  • Dysregulation of renal calcium transport during hypercalciuria and the pathophysiology of nephrocalcinosis
  • Homeostasis of the divalent cations, Ca2+ and Mg2+
  • The adaptive proliferation of epithelial tubular cells and homeostasis

The lab in a few pics :

facility for the functional analysis of kidney function

Research groups:

Gilles Crambert: Ionic transport and sex hormones        

Tel : +33 1 55 27 50 21

 mail@ : gilles.crambert@crc.jussieu.fr

 

Alain Doucet: Ionic transport and edema syndromes

Tel: +33 1 44 27 50 10

mail@ : alain.doucet@crc.jussieu.fr

 

Aurélie Edwards: Modeling of renal transport phenomena

Tel: + 33 1 44 27 50 99

 mail@ : aurelie.edwards@crc.jussieu.fr

 

Pascal Houillier: Calcium and magnesium homeostasis                        

 Tel: +33 1 44 27 50 29

 mail@ : pascal.houillier@inserm.fr

 

Kamel Laghmani: Molecular mechanisms of membrane trafficking

 Tel: + 33 1 44 27 50 68

 mail@ : kamel.laghmani@crc.jussieu.fr

 

 Gabrielle Planelles: Function and dysfunction of transport systems

Tel: +33 1 44 27 50 55

mail@: gabrielle.planelles@inserm.fr

 

Nicolas Picard:

Tel : +33 1 44 27 50 11

mail@: nicolas.picard@crc.jussieu.fr

 

Jacques Teulon: Ion channels

 Tel: +33 1 44 27 50 50 

 mail@ : jacques.teulon@crc.jussieu.fr

Contact:

Secretary:

 

 Dalila Haker 

 Tel:  + 33 1 44 27 50 03

 mail@ : dalila.haker.@crc.jussieu.fr

 Fax: +33 1 44 27 51 19

 

Address:

 

 Centre de Recherche des Cordeliers, UMRS 1138, ERL 8228

 Escalier J, rez-de-chaussée.

 15 rue de l'école de médecine

 75006 Paris

 

Last update : January, 2018